Endurant Stent Graft for Abdominal Aortic Aneurysm Repair Shows Durable Performance and Low Mortality Rates

Unveiling 10-Year Results: Durable Performance and Low Mortality Rates with Endurant Stent Graft

In a groundbreaking study presented at the Charing Cross Symposium, researchers have revealed the impressive 10-year results of the ENGAGE registry, shedding light on the enduring performance and low mortality rates associated with the Endurant stent graft for abdominal aortic aneurysm repair. The findings challenge previous concerns about the long-term durability of endovascular repair and underscore the critical need for lifelong surveillance for patients undergoing this procedure.

Extended Follow-Up Cohort: Key Characteristics

The extended follow-up cohort, comprising 390 patients, offered unique insights into the long-term outcomes of endovascular aneurysm repair. Patients in this cohort were found to be younger (average age of 70 years) compared to those not included, and they displayed a lower prevalence of comorbidities such as cardiac disease, pulmonary disease, renal insufficiency, cerebral vascular accident, or peripheral disease. These distinctions set the stage for a comprehensive evaluation of the Endurant stent graft’s performance in a subset of patients who may experience a different clinical trajectory.

Impressive Long-Term Outcomes: Freedom from Mortality and Intervention

Over the 10-year follow-up period, the rate of freedom from all-cause mortality in the extended follow-up cohort stood at a noteworthy 42.8%. Furthermore, the rate of freedom from aneurysm-related mortality was an impressive 94.7%. These results highlight the remarkable efficacy of the Endurant stent graft in preventing aneurysm-related deaths and solidify its position as a reliable treatment option for patients with abdominal aortic aneurysms.

Equally promising were the findings regarding aneurysm-related intervention rates. The study reported a 10-year freedom rate of 70.3% from such interventions, with no observed decline in performance as the follow-up period lengthened. This consistency suggests that the Endurant stent graft delivers durable results and provides patients with sustained protection against the need for reintervention.

Insights into Late Reinterventions and Endoleaks

Among the late reinterventions that occurred between 6 and 10 years, the majority were attributed to endoleaks, which primarily reflect the progression of aneurysm disease rather than graft occlusion. Intriguingly, 43% of patients with type Ia endoleaks exhibited specific characteristics such as a wide proximal neck, a short proximal neck, or an oversizing margin of 10% or less. Additionally, the study highlighted that late aneurysm rupture exclusively occurred in patients with an endoleak.

While 68 patients experienced an increase in sac size during the 6 to 10-year period, the remaining patients demonstrated sac regression. These nuanced observations emphasize the importance of meticulous surveillance and timely interventions in managing the complex interplay between aneurysm disease progression and the performance of the stent graft.

Reaffirming the Long-Term Efficacy: Lifelong Surveillance for EVAR Patients

Dr. Hence J.M. Verhagen, the lead researcher of the ENGAGE registry study, concluded that the 10-year data unequivocally confirm the enduring efficacy and durability of the Endurant stent graft. The study’s findings dispel concerns surrounding the long-term viability of endovascular repair and establish the stent graft as a reliable and effective treatment option for abdominal aortic aneurysm repair. Dr. Verhagen emphasized the pivotal role of lifelong surveillance, underscoring its criticality in ensuring optimal outcomes for patients undergoing endovascular repair.

In summary, the ENGAGE registry study has unveiled compelling 10-year data on the performance of the Endurant stent graft for abdominal aortic aneurysm repair. With low rates of aneurysm-related mortality and reintervention, this advanced medical technology offers a durable solution for patients seeking long-term protection. By showcasing the importance of lifelong surveillance, this study equips healthcare professionals with invaluable insights to optimize patient care and outcomes in the field of endovascular repair.